Synthesis of structurally diverse biflavonoids

Autor:	David G. Twigg, Tze Jing Sum, Warren R. J. D. Galloway, Tze Han Sum, Joe J. Ciardiello, David R. Spring
Rok vydání:	2018
Předmět:	Biflavonoids 010405 organic chemistry Drug discovery Chemistry Organic Chemistry 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry Chemical space Methylenedioxy 0104 chemical sciences chemistry.chemical_compound Drug Discovery
Zdroj:	Tetrahedron. 74:5089-5101
ISSN:	0040-4020
Popis:	Synthetic biflavonoids are associated with interesting biological activities, yet they remain poorly explored within drug discovery. Recent years have witnessed a growing interest in synthetic approaches that can provide access to structurally novel biflavonoids so that the biological usefulness of this compound class can be more fully investigated. Herein, we report upon the exploration of strategies based around Suzuki-Miyaura cross-coupling and alcohol methylenation for the synthesis of two classes of biflavonoids: (i) rare ‘hybrid’ derivatives containing flavonoid monomers belonging to different subclasses, and (ii) homodimeric compounds in which the two flavonoid monomers are linked by a methylenedioxy group. Application of these strategies enabled the preparation of a structurally diverse collection of novel biflavonoids from readily-available starting materials, thereby facilitating the probing of uncharted regions of biologically interesting chemical space.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f22cfeeb4e98de9ef68316ac8c313a48 https://doi.org/10.1016/j.tet.2018.05.003 Zobrazit plný text záznamu Full Text from ScienceDirect