Reactions of 2-ethoxycarbonyl(carboxy)-5,6,7,8-tetrafluorochromones with N-nucleophiles

Autor:	Oleg N. Chupakhin, Z. E. Skryabina, I. T. Bazyl, Viktor I. Saloutin
Rok vydání:	1994
Předmět:	chemistry.chemical_compound Aniline Nucleophile chemistry Nucleophilic aromatic substitution Methylamine Hexylamine Morpholine Substituent Organic chemistry Ethylenediamine General Chemistry Medicinal chemistry
Zdroj:	Russian Chemical Bulletin. 43:849-853
ISSN:	1573-9171 1066-5285
Popis:	The direction of reactions of 2-ethoxycarbonyl-5,6,7,8-tetrafluoro- and 2-carboxy-5,6,7,8-tetrafluorochromones with ammonia, methylamine, hexylamine, and aniline depends on the inductive effect of the substituent at position C-2 of the chromone and on the basicity of the amine. Nucleophilic aromatic substitution of a fluorine atom takes place in the interaction of 2-ethoxycarbonyl-5,6,7,8-tetrafluorochromone with secondary amines (morpholine,N-methylpiperazine) and ethylenediamine.
Databáze:	OpenAIRE
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