| Autor: |
Pei-Tseng Lee, Michelle N. Arbeitman, Ruei-Ying Tzeng, Hongru Hu, Julia C Fortier, Colleen M Palmateer, Pamela C Lovejoy, Savannah G Brovero, Nicole R. Newell, Kai Zinn |
| Rok vydání: |
2020 |
| Předmět: |
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| Popis: |
Drosophilareproductive behaviors are directed byfruitlessneurons (fru P1isoforms). A reanalysis of genomic studies shows that genes encodingdprandDIPImmunoglobulin superfamily (IgSF) members are expressed infru P1neurons. Eachfru P1anddpr/DIP(fru P1∩dpr/DIP) overlapping expression pattern is similar in both sexes, with dimorphism in neuronal morphology and cell number. Behavioral studies offru P1∩dpr/DIPperturbation genotypes point to the mushroom body functioning together with the lateral protocerebral complex. Functionally, we find that perturbations of sex hierarchy genes andDIP-εchanges sex-specific morphology offru P1∩DIP-αneurons. A single-cell RNA-seq analysis shows that theDIPshave high expression in a restricted set offru P1neurons, whereas thedprsare expressed in larger set of neurons at intermediate levels, with a myriad of combinations. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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