Characterization and regulated naproxen release of hydroxypropyl cyclosophoraose-pullulan microspheres
| Autor: | Jae-Hyuk Yu, Benel Lee, Seyeon Park, Seunho Jung, Kyeong Hui Park, Eunae Cho, Yong-Joon Jeon, Im-Soon Lee, Kyungho Lee, Sun Hee Do, Bong-Hyun Jun, Someshwar D. Dindulkar, Eun-Ji Choi, Jae Min Choi, Daham Jeong |
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| Rok vydání: | 2017 |
| Předmět: |
Naproxen
Thermogravimetric analysis General Chemical Engineering Kinetics Pullulan 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences chemistry.chemical_compound Solid-state nuclear magnetic resonance chemistry Drug delivery Emulsion medicine Organic chemistry Fourier transform infrared spectroscopy 0210 nano-technology Nuclear chemistry medicine.drug |
| Zdroj: | Journal of Industrial and Engineering Chemistry. 48:108-118 |
| ISSN: | 1226-086X |
| Popis: | Hydroxypropyl cyclosophoraose-pullulan (HPCys-Pul) microspheres were designed as a novel hybrid system of biocompatible pullulan matrice and pendant hydroxypropyl cyclosophoraoses with drug complexing ability. The HPCys-Pul microspheres were prepared by emulsion crosslinking method, and characterized using thermogravimetric analysis, Fourier transform infrared spectroscopy, scanning electron microscopy, and solid state NMR spectroscopy. By virtue of hydroxypropyl cyclosophoraoses, the developed microspheres can encapsulate 4.2-fold more naproxen than pullulan microspheres. Korsmeyer–Peppas model was introduced for describing release kinetics. In vivo naproxen release analysis was carried out in Sprague-Dawley (SD) rats. From those results HPCys-Pul microsphere will be a promising platform for controlled drug delivery. |
| Databáze: | OpenAIRE |
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