SARS-CoV-2 Antibody Response in Patients Undergoing Kidney Transplantation
| Autor: | Thalia Salinas, Zoe Kapur, Jehona Marku-Podvorica, Meredith J. Aull, John R. Lee, Rebecca Craig-Schapiro, Sophie Rand, Shady Albakry, Zhen Zhao, Darshana Dadhania, Nataliya Hauser, Michelle Lubetzky, Vijay K. Sharma, Sandip Kapur, Ashely Sukhu, Samuel Sultan, Melissa M. Cushing |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Coronavirus disease 2019 (COVID-19) biology business.industry Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) medicine.disease Gastroenterology Transplantation Immune system Internal medicine medicine biology.protein Avidity Antibody Neutralizing antibody business Kidney transplantation |
| Popis: | The response of the immune system to COVID-19 in end stage kidney disease patients who undergo kidney transplantation has yet to be described. We report data on 72 patients who underwent SARS-CoV-2 antibody testing both before and after kidney transplantation and were followed for a median of 186 days (range 83, 277). Of the 25 patients with a positive antibody test at the time of transplant, 17 (68%) remained positive after transplantation. Patients were significantly more likely to have a persistently positive test if they reported a symptomatic COVID-19 infection prior to transplant (p=0.01). SARS-CoV-2 IgG index values were measured in a subset of kidney transplant recipients and compared to wait -listed dialysis patients. These assays demonstrated a more significant decline in IgG (58% versus 14% p = 0.008) in transplant recipients when compared to dialysis patients tested during the same time period. Additional analysis of the quality of the immune response measuring the binding of SARS-CoV-2 antibodies to the receptor-binding domain (RBD binding), the antibody neutralizing capability, and the antibody avidity demonstrated a more pronounced effect when comparing pre-transplant values to post-induction therapy/post transplant values. The attenuated IgG response seen in transplant patients compared to dialysis patients after induction therapy requires further study. These data have important implications for post-transplant management of vaccinated dialysis patients. |
| Databáze: | OpenAIRE |
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