Design, synthesis of novel antifungal triazole derivatives with high activities against Aspergillus fumigatus
| Autor: | Chao Mei Liu, Yong Bing Cao, Qiu Qin He, Ke Li |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Antifungal
biology Stereochemistry medicine.drug_class Itraconazole Lanosterol Triazole Active site General Chemistry biology.organism_classification Chemical synthesis Aspergillus fumigatus chemistry.chemical_compound chemistry biology.protein Triazole derivatives medicine skin and connective tissue diseases medicine.drug |
| Zdroj: | Chinese Chemical Letters. 18:421-423 |
| ISSN: | 1001-8417 |
| DOI: | 10.1016/j.cclet.2007.02.011 |
| Popis: | Based on the active site of Aspergillus fumigatus lanosterol 14α-demethylase (AF-CYP51), novel triazole compounds were designed. Their chemical synthesis and the antifungal activities were reported. The results showed that all the target compounds exhibited excellent activities with broad spectrum; in which compounds 4, 12 and 15 showed comparable activities against A. fumigatus to the control drug itraconazole. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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