Allowing for Two Different Mechanisms by which Lesion Free Lung Lobes Occur in Pigs After an Experimental Challenge: Vaccine Performance Comparisons
Autor: | A. C. Trajstman |
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Rok vydání: | 2001 |
Předmět: | |
Zdroj: | Biometrical Journal. 43:323-341 |
ISSN: | 1521-4036 0323-3847 |
DOI: | 10.1002/1521-4036(200106)43:3<323::aid-bimj323>3.0.co;2-h |
Popis: | To compare vaccine performances in a pig pneumonia vaccine trial it is necessary to account for two mechanisms by which lesion-free lung lobes may occur in pigs that have been experimentally challenged. A challenge may not establish in a pig and therefore necessarily there will be no lobe lesions. On the other hand a challenge may be established but the vaccine may prevent lobe lesions from developing. Therefore a model is required that unravels the nexus between the two mechanisms of generating pigs without any lung lesions. Some models are proposed based on zero-modified distributions. Vaccine performance may then be assessed using a number of criteria. Data from an actual pig pneumonia vaccine trial are used as an illustration. |
Databáze: | OpenAIRE |
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