Allowing for Two Different Mechanisms by which Lesion Free Lung Lobes Occur in Pigs After an Experimental Challenge: Vaccine Performance Comparisons

Autor:	A. C. Trajstman
Rok vydání:	2001
Předmět:	Statistics and Probability Lung business.industry Vaccine trial General Medicine medicine.disease Lesion Pneumonia medicine.anatomical_structure Lung disease Immunology medicine Statistics Probability and Uncertainty medicine.symptom business Experimental challenge
Zdroj:	Biometrical Journal. 43:323-341
ISSN:	1521-4036 0323-3847
DOI:	10.1002/1521-4036(200106)43:3<323::aid-bimj323>3.0.co;2-h
Popis:	To compare vaccine performances in a pig pneumonia vaccine trial it is necessary to account for two mechanisms by which lesion-free lung lobes may occur in pigs that have been experimentally challenged. A challenge may not establish in a pig and therefore necessarily there will be no lobe lesions. On the other hand a challenge may be established but the vaccine may prevent lobe lesions from developing. Therefore a model is required that unravels the nexus between the two mechanisms of generating pigs without any lung lesions. Some models are proposed based on zero-modified distributions. Vaccine performance may then be assessed using a number of criteria. Data from an actual pig pneumonia vaccine trial are used as an illustration.
Databáze:	OpenAIRE
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