Expression of midkine and endoglin in breast carcinomas with different immunohistochemical profiles
Autor: | Hui Lian Huang, Jing Li, Wei Xu, Li Cheng Dai, Li Qin Li, Jin Liang Ping |
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Rok vydání: | 2010 |
Předmět: |
Microbiology (medical)
Midkine Pathology medicine.medical_specialty biology business.industry Cancer General Medicine Endoglin medicine.disease Pathology and Forensic Medicine Breast cancer Antigen biology.protein medicine Cancer research Immunology and Allergy Immunohistochemistry Breast disease Breast carcinoma business |
Zdroj: | APMIS. 119:103-110 |
ISSN: | 0903-4641 |
Popis: | The aim of this study was to investigate the midkine and endoglin expression in breast carcinomas with five different immunohistochemical profiles and their relevance to histopathologic and clinicopathologic features. We analyzed 161 archival tissues immunohistologically. The level of midkine expression in breast cancer significantly correlated with lymph node metastasis (p = 0.001) and TNM staging (p = 0.003). High microvessel density (MVD) was associated with higher midkine reactivity group (p = 0.036). Although the basal-like subtype had higher midkine expression level and MVD, no significant difference with the other breast cancer subtypes was found. In conclusion, midkine was a promising target for tumor prognosis in clinical diagnosis and treatment. This study found no significant differences in tumor angiogenesis in different molecular subtypes of breast cancer. |
Databáze: | OpenAIRE |
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