A one-pot method for the preparation of 2,5-diarylthiophene-1-oxides from arylacetylenes

Autor:	Adam C. Whalley, Eleanor M. Fortner-Buczala, Robert W. Miller, Adam M. Dyer, Nicholas J. Dodge
Rok vydání:	2016
Předmět:	010405 organic chemistry Chemistry Product (mathematics) Organic Chemistry Drug Discovery Diels alder Organic chemistry 010402 general chemistry 01 natural sciences Biochemistry Thiophene derivatives 0104 chemical sciences
Zdroj:	Tetrahedron Letters. 57:1860-1862
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2016.03.051
Popis:	2,5-Diarylthiophene-1-oxides have been prepared from readily available arylacetylene precursors via zirconacyclopentadiene intermediates. The isolated yields of the desired thiophene-1-oxides are comparable to those obtained from the oxidation of thiophene derivatives while avoiding the formation of over-oxidation products. Furthermore, this route offers broader versatility than commonly used methods by providing products outfitted with electron-donating or electron-withdrawing groups with very little variation in isolated product yields. Finally, this strategy provides access to products containing functional groups that are not compatible with oxidation conditions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f1fd38d6f6ce83ba17546c43daea60f6 https://doi.org/10.1016/j.tetlet.2016.03.051 Zobrazit plný text záznamu Full Text from ScienceDirect