| Popis: |
Summary 1. A case of generalized histoplasmosis in a male infant, 11 months of age, with autopsy, mycologic, and experimental studies is reported. Lesions were found in the lungs, liver, spleen, adrenal glands, kidneys, colon, appendix, bone marrow, lymph nodes, and blood vessels. 2. Macroscopically visible colonies of Histoplasma capsulatum were observed on blood agar plates (indubated aerobically at room temperature) on the fourth day following inoculation with blood taken from the heart at autopsy. 3. Yeast like forms of the fungus were observed in blood films prepared post mortem. 4. Experiments indicate that Histoplasma capsulatum is resistant to drying and to low temperatures (from 5 to 8° C.). 5. Histoplasma capsulatum is destroyed in milk by heating at from 62 to 63° C. for twenty minutes. 6. Infection of guinea pigs, normal and vitamin C deficient, could not be established by oral feedings with large numbers of organisms. |
