Steroid Receptor RNA Activator Protein (SRAP): A Potential New Prognostic Marker for Estrogen Receptor-Positive/Node-Negative/Younger Breast Cancer Patients

Autor:	Y. Yan, G. Skliris, C. Penner, S. Chooniedass-Kothari, C. Cooper, Z. Nugent, A. Fristenski, M. Hamedani, A. Blanchard, Y. Myal, L. Murphy, E. Leygue
Rok vydání:	2009
Předmět:	Oncology Cancer Research medicine.medical_specialty biology business.industry RNA Cancer Estrogen receptor medicine.disease Non-coding RNA Breast cancer Internal medicine Immunology medicine biology.protein Immunohistochemistry Antibody Receptor business
Zdroj:	Cancer Research. 69:2017-2017
ISSN:	1538-7445 0008-5472
DOI:	10.1158/0008-5472.sabcs-09-2017
Popis:	Purpose: The steroid receptor RNA activator (SRA) is a functional RNA suspected to participate in the mechanisms underlying breast tumor progression. This RNA is also able to encode for a protein, SRAP, whose exact function remains to be determined. Our aim was to assess, in a large breast cancer cohort, whether levels of this protein could be associated with outcome or established clinical parameters.Experimental Design: Following antibody validation, we have assessed SRAP expression by tissue-microarray (TMA) analysis of 372 tumors with known steroid receptor and node status. Clinical follow-up was available for all the corresponding patients. Immunohistochemical scores were independently determined by two investigators and averaged. Statistical analyses were performed using standard univariate and multivariate tests.Results: SRAP levels were significantly (Mann-Whitney rank sum test, P Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 2017.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f1ef33b8196954c2b4d5c1f46df000e8 https://doi.org/10.1158/0008-5472.sabcs-09-2017 Zobrazit plný text záznamu