At the outer edge of STEMI time: even after 12 hours, the clock keeps ticking
| Autor: | M Martinho, R Cale, S Nabais, A Briosa, E Pereira, A R Pereira, J Grade Santos, B Ferreira, D Santos Cunha, P Santos, S Vitorino, C Eusebio, G Morgado, C Martins, H Pereira |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | European Heart Journal. 43 |
| ISSN: | 1522-9645 0195-668X |
| DOI: | 10.1093/eurheartj/ehac544.1239 |
| Popis: | Introduction Although primary percutaneous coronary intervention (pPCI) is not a class I recommendation in all patients (pts) presenting within 12 to 48h of symptom onset (late ST-segment Elevation Myocardial Infarction, STEMI), there is increasing evidence supporting its routine use in this population. Data on long-term clinical outcomes is sparse. Objective To evaluate long-term MACE in late-STEMI pts submitted to pPCI and compare with clinical outcomes of early reperfusion groups. Methods Retrospective analysis of consecutive pts submitted to pPCI due to STEMI between 2010 and 2015 in a pPCI centre. Included pts were stratified in 5 groups according to symptom-to-balloon time (SBT): 48h. Long-term events were established as 5y mortality and 5y-MACE (a composite endpoint of death, re-infarction, heart failure hospital admission and ischemic stroke). The cumulative incidence of long-term outcomes was calculated by the Cox regression analysis and presented according to the Kaplan-Meier method. Results Of the 884 pts included in the study, stratification according to SBT was: pPCI Conclusions As expected, there is a clinical benefit of early reperfusion for long-term cardiovascular events. Within the late-STEMI group, there seems to be a clear distinction between pPCI24h, although the clinical benefit of pPCI timing most probably acts a continuum. Funding Acknowledgement Type of funding sources: None. |
| Databáze: | OpenAIRE |
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