Computational and performance analysis of a continuous magnetophoretic bioseparation chip with alternating magnetic fields
| Autor: | Matin Golozar, Jeff Darabi, Majid Molki |
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| Rok vydání: | 2017 |
| Předmět: |
Materials science
010401 analytical chemistry Microfluidics Nanotechnology 02 engineering and technology equipment and supplies 021001 nanoscience & nanotechnology Condensed Matter Physics Chip 01 natural sciences 0104 chemical sciences Electronic Optical and Magnetic Materials Volumetric flow rate Magnetic field Magnet Materials Chemistry Magnetic nanoparticles Fluidics 0210 nano-technology Biological system human activities Parametric statistics |
| Zdroj: | Microfluidics and Nanofluidics. 21 |
| ISSN: | 1613-4990 1613-4982 |
| DOI: | 10.1007/s10404-017-1909-4 |
| Popis: | This paper presents the modeling and optimization of a magnetophoretic bioseparation chip for isolating cells, such as circulating tumor cells from the peripheral blood. The chip consists of a continuous-flow microfluidic platform that contains locally engineered magnetic field gradients. The high-gradient magnetic field produced by the magnets is spatially non-uniform and gives rise to an attractive force on magnetic particles flowing through a fluidic channel. Simulations of the particle–fluid transport and the magnetic force are performed to predict the trajectories and capture lengths of the particles within the fluidic channel. The computational model takes into account key forces, such as the magnetic and fluidic forces and their effect on design parameters for an effective separation. The results show that the microfluidic device has the capability of separating various cells from their native environment. An experimental study is also conducted to verify and validate the simulation results. Finally, to improve the performance of the separation device, a parametric study is performed to investigate the effects of the magnetic bead size, cell size, number of beads per cell, and flow rate on the cell separation performance. |
| Databáze: | OpenAIRE |
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