Cholinergic depolarization recruits a persistent Ca2+ current in Aplysia bag cell neurons

Autor:	Kelly H. Lee, David E. Wassef, Eammon K. MacNeil, Neil S. Magoski
Rok vydání:	2023
Předmět:	Physiology General Neuroscience
Zdroj:	Journal of Neurophysiology. 129:1045-1060
ISSN:	1522-1598 0022-3077
DOI:	10.1152/jn.00429.2022
Popis:	Ionotropic acetylcholine receptors mediate brief synaptic communication, including in bag cell neurons of the sea snail Aplysia. However, this study demonstrates that cholinergic depolarization can open a voltage-gated persistent Ca2+ current, which extends the bag cell neuron response to acetylcholine. Bursting in these neuroendocrine cells results in hormone release and egg laying. Thus, this emphasizes the role of ionotropic signaling in reaching a depolarized level to engage Ca2+ influx and perpetuating the activity necessary for behavior.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f1ea161f6ee4ebb2ed4c9441612640c8 https://doi.org/10.1152/jn.00429.2022 Zobrazit plný text záznamu