Light scattering measurements of retinal biomarkers of Alzheimer’s disease guided by low-cost optical coherence tomography

Autor:	Zachary A. Steelman, L. Martin, Adam Wax, Ziyun Yang, Vadim Y. Arshavsky, Kengyeh K. Chu, Ge Song, Stella Finkelstein, Sina Farsiu
Rok vydání:	2021
Předmět:	Physics Modality (human–computer interaction) genetic structures medicine.diagnostic_test Coherent imaging Retinal Image segmentation Light scattering Interferometry chemistry.chemical_compound Optical coherence tomography chemistry medicine Retinal imaging sense organs Biomedical engineering
Zdroj:	Biomedical Applications of Light Scattering XI.
DOI:	10.1117/12.2576911
Popis:	We present results from depth-resolved light scattering measurements of triple transgenic mouse retinas for Alzheimer’s Disease (AD) using a multimodal coherent imaging system. Use of a co-registered angle-resolved low-coherence interferometry (a/LCI) and optical coherence tomography (OCT) system allows unique analysis that is otherwise unavailable using a single modality to provide complementary information on tissue structural changes associated with AD. This abstract summarizes the light scattering parameters drawn using this system at selective retinal layers guided by OCT image segmentation. Future developments of this combined system for human retinal imaging, which involve a low-cost OCT engine, are also discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f1e7dd7198103f0c3ab73ff4b2cba266 https://doi.org/10.1117/12.2576911 Zobrazit plný text záznamu