Polyploidy in the myocardium and compensatory reserve of the heart

Autor:	V. Ya. Brodskii
Rok vydání:	1995
Předmět:	medicine.medical_specialty Ontogeny Heart growth Compensatory growth (organ) food and beverages General Medicine Biology Gene dosage General Biochemistry Genetics and Molecular Biology Muscle hypertrophy Endocrinology Polyploid Internal medicine medicine Myocyte Ploidy
Zdroj:	Bulletin of Experimental Biology and Medicine. 119:435-440
ISSN:	1573-8221 0007-4888
Popis:	The mammalian heart is a polyploid organ. Cardiac myocytes undergo polyploidization in the early postnatal ontogeny, and the degree of their polyploid depends on the conditions of heart growth. The myocardium of healthy persons is characterized by considerable individual variability of polyploidy. The principal mechanism by which normal and compensatory growth of the heart occurs in adult mammals is through increases of cytoplasmic mass in postmitotic myocytes. In the normal myocardium, the protein mass of myocytes does not correspond to the gene dosage, while their protein mass in a hypertrophic myocardium becomes a multiple of their ploidy. The capacity of polyploid myocytes to grow so as to double their mass constitutes the reserve of cardiac growth. This reserve, which is laid down in the early ontogeny, materializes in response to functional overloading of the heart in adult life.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f1d95be1302ca95a4b5b7a74e3eebe65 https://doi.org/10.1007/bf02543423 Zobrazit plný text záznamu Full text from SpringerLink