Myelin proteolipid proteins promote the interaction of oligodendrocytes and axons

Autor: Donald Yool, Klaus-Armin Nave, L Dimou, Demetrius A. Vouyiouklis, Jennifer A. Barrie, M. C. McCulloch, Marie McLaughlin, Matthias Klugmann, Ian R. Griffiths
Rok vydání: 2001
Předmět:
Zdroj: Journal of Neuroscience Research. 63:151-164
ISSN: 1097-4547
0360-4012
DOI: 10.1002/1097-4547(20010115)63:2<151::aid-jnr1007>3.0.co;2-y
Popis: Although proteolipid protein (PLP) and its DM20 isoform are the major membrane proteins of CNS myelin, their absence causes surprisingly few developmental defects. In comparison, missense mutations of the X-linked Plp gene cause severe dysmyelination. Previous studies have established roles for PLP/DM20 in the formation of the intraperiod line and in maintaining axonal integrity. We now show that a normal number of oligodendrocytes are present in mice lacking PLP/DM20. However, in heterozygous females, which are natural chimeras for X-linked genes, oligodendrocytes lacking PLP/DM20 are in direct competition with wild-type oligodendrocytes that have a distinct advantage. PLP 1 oligodendrocytes and PLP 1 myelin sheaths make up the greater majority, and this feature is generalised in the CNS throughout life. Moreover, in the absence of PLP/DM20, a proportion of small-diameter axons fails to myelinate, remaining ensheathed but lacking a compact sheath, or show delayed myelination. These findings suggest that PLP/DM20 is also involved in the early stages of axon‐ oligodendrocyte interaction and wrapping of the axon. J. Neurosci. Res. 63:151‐164, 2001. © 2001 Wiley-Liss, Inc.
Databáze: OpenAIRE
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