CD20-mediated apoptosis: signalling through lipid rafts

Autor:	Julie P. Deans, Haidong Li, Maria J. Polyak
Rok vydání:	2002
Předmět:	Kinase Effector Chemistry Immunology Cell biology Mechanism of action Apoptosis hemic and lymphatic diseases medicine Immunology and Allergy medicine.symptom Tyrosine Cytotoxicity Lipid raft Tyrosine kinase
Zdroj:	Immunology. 107:176-182
ISSN:	1365-2567 0019-2805
DOI:	10.1046/j.1365-2567.2002.01495.x
Popis:	CD20 is an effective target for therapeutic B-cell depletion with monoclonal antibodies. One proposed mechanism of action is direct cytotoxicity mediated via tyrosine kinase-dependent signalling pathways activated upon CD20 cross-linking. The association of CD20 with membrane microdomains known as lipid rafts, enriched in src-family tyrosine kinases and other signalling effectors, suggests an indirect mechanism of anti-CD20-induced apoptosis in which activation of src-family kinases occurs as a consequence of lipid raft clustering.
Databáze:	OpenAIRE
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