T Cell Recovery in T-ALL After Transplantation of Autologous BM Purged with Anti-T(WT1)-Coupled to Ricin
| Autor: | E. J. E. G. Bast, Peter J.A. Capel, Th. de Witte, L. F. Verdonck, F. Preyers, G.C. de Gast |
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| Rok vydání: | 1985 |
| Předmět: |
Autologous bmt
business.industry medicine.drug_class medicine.medical_treatment T cell medicine.disease_cause Monoclonal antibody Transplantation Radiation therapy chemistry.chemical_compound Herpes simplex virus Ricin medicine.anatomical_structure chemistry Cancer research Medicine business Lymphocyte stimulation |
| Zdroj: | 11th Annual meeting of the EBMT ISBN: 9783662393994 |
| DOI: | 10.1007/978-3-662-40457-7_114 |
| Popis: | Patients with a T-ALL and hyperleukocytosis have a bad prognosis, which may be improved by consolidation by high dose chemo/radiotherapy and autologous BMT. To minimize the chance of returning leukemic T cells, the bone-marrow graft can be treated with immuno-toxines such as ricin A coupled monoclonal antibodies. The effect of this procedure on T cell recovery and relapse is not known. In this case report T cell recovery appeared to be normal in such a patient. |
| Databáze: | OpenAIRE |
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