Interactions Between non-ionic Surfactant Vesicles and human stratum corneumin vitro

Autor:	F. Spies, Christopher Cullander, Hans E. Junginger, H. E. J. Hofland, Nagelkerke Jf, Harry E. Boddé, Joke A. Bouwstra
Rok vydání:	1995
Předmět:	Liposome integumentary system Chemistry Vesicle Bilayer Analytical chemistry Pharmaceutical Science Ether law.invention chemistry.chemical_compound medicine.anatomical_structure Adsorption Pulmonary surfactant law Stratum corneum medicine Biophysics Electron microscope
Zdroj:	Journal of Liposome Research. 5:241-263
ISSN:	1532-2394 0898-2104
DOI:	10.3109/08982109509018629
Popis:	The effects of non-ionic surfactant vesicles (NSVs) on human skin in vitro were studied in relation to the physico-chemical properties of the vesicles. The interactions between NSVs and skin were visualized using both freeze fracture electron microscopy and confocal laser scanning microscopy. The physico-chemical properties of the NSVs were varied in a systematic way, using a broad series of polyoxyethylene monoalkyl ether type surfactants (CnEOm). The number of oxyethylene units (m) was varied between 3, 7 and 10, and the number of carbon atoms (n) was either 12 or 18. Both the effects of liquid state vesicles composed of C12Eo3,7 and C9=9EO10 surfactants and gel state vesicles (C18EO37) were investigated. After the application of the NS V suspension on the stratum corneum surface two essentially different types of vesicle-skin interactions were visualized. Firstly, an interfacial interaction, involving the adsorption of vesicles, and the deposition of bilayer sheets on the outermost layers of th...
Databáze:	OpenAIRE
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