Preliminary investigation of a new serum marker for ovarian cancer
| Autor: | R. Soeters, P. D. van Helden, J Nevin, R H Laeng, S Bird, Hanne Veenstra, M H Botha, W K Van der Merwe, L. Van Wijk |
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| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Southern African Journal of Gynaecological Oncology. 4:13-20 |
| ISSN: | 2220-105X 2074-2835 |
| Popis: | Objectives: The long-term survival rate of patients with carcinoma of the ovary is poor, because this condition is usually diagnosed at an advanced stage of the disease. A reliable diagnostic and screening test is still lacking. Therefore, a serological test for a novel ovarian tumour antigen was developed and investigated in a clinical setting. This report describes this investigation, the aim of which was to provide data to decide whether the test warrants a further, large-scale trial.Methods: Serum collected from 25 patients with ovarian carcinoma, 24 healthy controls and 25 control patients with non-carcinomatous ovarian disorders was tested. The test utilises a monoclonal antibody, designated SMO47, to capture the tumour antigen and a normal form of the antigen from serum. Only the tumour antigen is detected by biotinylated Maakia amurensis lectin, which binds specifically to the sialic acid on the tumour antigen.Results: The sensitivity for the carcinoma patient group was 60% and the specifi... |
| Databáze: | OpenAIRE |
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