Steroidal saponins with cytotoxic activity from the rhizomes of Paris polyphylla var. yunnanensis

Autor:	Yan-Shi Wen, Yan Hua, Xu-Jie Qin, Hai-Yang Liu, Huan Yan, Li He, Yung-Chi Cheng, Wei Ni, Chang-Xiang Chen
Rok vydání:	2015
Předmět:	Traditional medicine Paris polyphylla Plant Science Biology biology.organism_classification Biochemistry Rhizome Phytochemical Botany Ic50 values Cytotoxic T cell Paris polyphylla var. yunnanensis Cancer cell lines Agronomy and Crop Science Human cancer Biotechnology
Zdroj:	Phytochemistry Letters. 12:31-34
ISSN:	1874-3900
Popis:	Two previously unreported spirostanol saponins, dianchonglouosides A and B (1 and 2), along with 7 known steroidal saponins (3-9) were isolated from the rhizomes of Paris polyphylla var. yunnanensis. Their structures were elucidated by extensive spectroscopic analysis (MS, 1D, and 2D NMR), and chemical methods. The cytotoxic activities of the isolated compounds 1-9 were also evaluated against two human cancer cell lines (HEK293 and HepG2). The results showed that compound 7 had the strongest cytotoxic activity against the two cancer cell lines with the IC50 values of 0.6 and 0.9 mM, respectively. (C) 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f1c38865f76b9209a7b37d00cefc0950 https://doi.org/10.1016/j.phytol.2015.02.011 Zobrazit plný text záznamu Full Text from ScienceDirect