Comparison of ultrasound scattering behavior of optison and a liquid perflourocarbon nanoparticle contrast agent
| Autor: | Michael Hughes, Greg Lanza, Ralph Furhop, Jon N. Marsh, Lori Chinen, Sam Wickline |
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| Rok vydání: | 2001 |
| Předmět: |
Materials science
Acoustics and Ultrasonics Scattering business.industry Attenuation media_common.quotation_subject Hydrostatic pressure Ultrasound Second-harmonic imaging microscopy Nuclear magnetic resonance Arts and Humanities (miscellaneous) Attenuation coefficient Emulsion Contrast (vision) business media_common |
| Zdroj: | The Journal of the Acoustical Society of America. 110:2614-2614 |
| ISSN: | 0001-4966 |
| Popis: | Useful ultrasound contrast enhancement has been obtained using liquid emulsion contrast agents developed in our laboratory [Evaluation of liquid perflourocarbon nanoparticles as a blood pool contrast agent utilizing power Doppler harmonic imaging, IEEE Ultrason. Symp. 00CH37121, 1931–1934 (2000)]. While the physical basis for enhancement is unknown, it is reproducible, in vivo and in vitro. It is hypothesized that microbubble formation is not a significant factor in the acoustic behavior of these contrast agents; attenuation and backscatter (measured in a water bath at 37 °C) are uneffected by changes in hydrostatic pressure (from −50 to 200 mm Hg), acoustic pressure (0.038–3.0 MPa), and show no evidence of scattering agent destruction with ultrasound exposure time (2–80 s). The microbubble agent attenuation coefficient exhibits a single peak between 1 and 2 MHz. The exact peak location, height and width vary significantly with experimental conditions. In contrast, the emulsion does not exhibit any of ... |
| Databáze: | OpenAIRE |
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