Stereoselective Michael addition of 6-amino-1,3-dimethyl-2,4-pyrimidinedione to the exocyclic methylene of three sesquiterpene lactones.1H and13C NMR evidence of a new C-C bond and lactam formation

Autor:	Jose Fernando Fuentes, León G. Leticia, Fuentes B. Aidee, Angelina Quintero, José D. Solano, Eduardo Dfaz, Jose Luis Nava, Raúl G. Enríquez, Héctor Barrios, Angel Guzman
Rok vydání:	1997
Předmět:	chemistry.chemical_classification chemistry.chemical_compound chemistry Pyrimidine Stereochemistry Organic Chemistry Pyrimidinedione Lactam Michael reaction Stereoselectivity Methylene Derivative (chemistry) Lactone
Zdroj:	Journal of Heterocyclic Chemistry. 34:1037-1041
ISSN:	1943-5193 0022-152X
DOI:	10.1002/jhet.5570340351
Popis:	The Stereoselective addition of the pyrimidine derivative 1 to the exocyclic methylene of the α,β unsaturated dehydrocostus lactone 2, Ivalin acetate 3 and Zaluzanin A diacetate 4, was achieved resulting in a new C-C bond formation. In the cases of compounds 3 and 4, after the addition, the lactone was cleaved followed by reclosure into a lactam ring system.
Databáze:	OpenAIRE
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