| Popis: |
Summary The ability to construct recombinant viruses expressing foreign genes clearlyhas great potential for vaccine development. In the case of rabies, the V-RG virus has proved to be highly immunogenic, and has outperformed conventional rabies vaccines in every comparative protection test. The question remains, however, whether recombinant vaccines based on vaccinia viruses will ever be accepted for human or veterinary use. In this regard, it should be noted that the lessons learned in the construction and evaluation of V-RG virus can be rapidly applied for the development of other recombinant viruses (bases on adenoviruses, for example). |
