THE ROLE OF LABORATORY BIOMARKERS IN MONITORING THE EFFECTIVENESS OF TREATMENT WITH INHIBITORS OF TUMOR NECROSIS FACTOR а IN RHEUMATOID ARTHRITIS

Autor:	L.N. Shilova, A.V. Alexandrov, Experimental Rheumatology named after А.B. Zborovsky, S.S. Dotsenko, P.A. Bakumov
Rok vydání:	2018
Předmět:	Oncology medicine.medical_specialty business.industry Rheumatoid arthritis Internal medicine medicine Tumor necrosis factor alpha medicine.disease business
Zdroj:	Journal of Volgograd State Medical University. 15:32-34
ISSN:	1994-9499 1994-9480
DOI:	10.19163/1994-9480-2018-2(66)-32-34
Popis:	Currently there are several biological therapy drugs used in the treatment of rheumatoid arthritis (RA), in connection with which there was a problem of choosing a drug. Materials and methods. 18 patients with rheumatoid arthritis, who received combination therapy with methotrexate and infliximab were examined. All patients before the start of treatment with infliximab and after 30 weeks were determined in the blood serum of TNF-α, IL-1, IL-2, IL-6. Results and conclusions. Hyperproduction of proinflammatory cytokines again confirms their participation in the development and progression of the RA. Increased levels of TNF-α, IL-1, IL-2 are more likely associated with a moderate effect of the conducted gene therapy at minimal and medium therapeutic dosages.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f1bf5979b3a2839a4b7d79e8caabefb8 https://doi.org/10.19163/1994-9480-2018-2(66)-32-34 Zobrazit plný text záznamu