Effects of Cadmium on the Activity of Matrix Metalloproteinases and Metallothionein Level in the Rat Brain
| Autor: | A. Shevtsova, O. Z. Fomenko, Honore N Shiyntum, O. Shaulska, Galyna Ushakova |
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| Rok vydání: | 2017 |
| Předmět: |
Cadmium
medicine.medical_specialty Cerebellum MMP2 Physiology General Neuroscience chemistry.chemical_element Hippocampus 030204 cardiovascular system & hematology Matrix metalloproteinase MMP9 Rat brain 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Endocrinology chemistry Internal medicine medicine Metallothionein 030217 neurology & neurosurgery |
| Zdroj: | Neurophysiology. 49:154-157 |
| ISSN: | 1573-9007 0090-2977 |
| DOI: | 10.1007/s11062-017-9645-7 |
| Popis: | We studied the effects of long-lasting treating with cadmium in two different doses (0.1 and 1.0 μg/kg) on the activity of matrix metalloproteinases (MMP2 and MMP9) and metallothionein level in the rat brain. Cadmium in a higher dose (1 μg/kg) caused a decrease in MMP2 activity but increased that of proMMP9 in the brain. The level of MT in the hippocampus and cerebellum dropped with both Cd doses. Thus, even small Cd doses exert specific effects on the MMP activity and MT level in the brain. |
| Databáze: | OpenAIRE |
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