Noviose mimics of the coumarin inhibitors of gyrase B

Autor:	Claudine Dupuis-Hamelin, Patrick Laurin, Periers Anne-Marie, Patrice Lassaigne, Branislav Musicki, Alain Bonnefoy, Michel Klich, Laurent Piombo
Rok vydání:	2003
Předmět:	medicine.drug_class Stereochemistry Organic Chemistry Antibiotics Biological activity Coumarin Biochemistry DNA gyrase In vitro chemistry.chemical_compound chemistry Drug Discovery medicine heterocyclic compounds Piperidine
Zdroj:	Tetrahedron Letters. 44:9259-9262
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2003.10.076
Popis:	The design, synthesis, and biological activity in vitro of modified coumarin inhibitors of gyrase B are presented. Noviose, the sugar portion of coumarin antibiotics, was replaced by simplified mimics, a 5′,5′-dimethylcyclohexane or piperidine.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f1bbde1b9869d1e16befca3ffb510d4c https://doi.org/10.1016/j.tetlet.2003.10.076 Zobrazit plný text záznamu Full Text from ScienceDirect