Impact of solutol HS 15 on the pharmacokinetic behaviour of colchicine upon intravenous administration to male Wistar rats
| Autor: | Beate Bittner, Roberto Carlos Bravo González, Isabelle Walter, Martin Kapps, Jörg Huwyler |
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| Rok vydání: | 2003 |
| Předmět: |
Pharmacology
Volume of distribution medicine.medical_specialty Chromatography Alkaloid Metabolite Pharmaceutical Science General Medicine Urine chemistry.chemical_compound Endocrinology chemistry Pharmacokinetics Free fraction Internal medicine Blood plasma medicine Colchicine Pharmacology (medical) |
| Zdroj: | Biopharmaceutics & Drug Disposition. 24:173-181 |
| ISSN: | 0142-2782 |
| Popis: | In the current investigation, the alkaloid colchicine was administered intravenously to male Wistar rats both as a solution in isotonic sodium chloride (NaCl 0.9%, control group) and in NaCl 0.9%:Solutol HS 15 (95:5) at 1.5 mg/kg. At predetermined time points, plasma and urine were collected from the animals and analysed for colchicine and its demethylated metabolites by LC/MS-MS. In the presence of Solutol HS 15, colchicine clearance (CI) was significantly decreased and its maximum plasma concentration (c(max)) was significantly increased as compared to the control group (CI: 15.6+/-7.0 ml/min/kg vs 34.3+/-2.3 ml/min/kg; c(max) 3055.1+/-587.4 h vs 1260.1+/-223.7 h; p |
| Databáze: | OpenAIRE |
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