The synthesis of 1-[(1-methylethyl) amino]-3-{[(4-methyl-thio)-1-naphthalenyl]OXY}-2-propanol hydrochloride-naphthalene-1114C: 4′-methylthiopropranolol
| Autor: | D. F. Gransden, I. T. Takahashi, G. A. Roth |
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| Rok vydání: | 1983 |
| Předmět: |
Chromatography
Hydrochloride Organic Chemistry Liquid scintillation counting Thio Free base Biochemistry High-performance liquid chromatography Analytical Chemistry Propanol chemistry.chemical_compound chemistry Yield (chemistry) Drug Discovery Radiology Nuclear Medicine and imaging Spectroscopy Nuclear chemistry Naphthalene |
| Zdroj: | Journal of Labelled Compounds and Radiopharmaceuticals. 20:1073-1085 |
| ISSN: | 0362-4803 |
| DOI: | 10.1002/jlcr.2580200905 |
| Popis: | The antihypertensive drug, 1-[(1-methylethyl)amino]-3-{[(4-methylthio)-1-naphthalenyl ]oxy} -2-propanol hydrochloride has been labeled with carbon-14 in the 1-position of the naphthalene. A total of 18.76 mCi was prepared in five steps starting with 1-naphthol-1-14C. The overall yield for the synthesis was 33.6% following five recrystallizations of the free base. The radiochemical purity of the hydrochloride product was 98.0% by high pressure liquid chromatography (HPLC)/liquid scintillation counting (LSC). The specific activity of the product was found to be 11.68 ∓ 0.45 mCi/mmole. Structural confirmation was done by infrared spectroscopy. |
| Databáze: | OpenAIRE |
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