Filtration Studies on Reactive Infusion Fluids
| Autor: | Co Tui, K. L. McCloskey, A. L. Yates, M. H. Schrift |
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| Rok vydání: | 1936 |
| Předmět: | |
| Zdroj: | Experimental Biology and Medicine. 35:297-300 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-35-8946p |
| Popis: | This is a report of attempts to remove by various methods of filtration the reactive agent or agents from infusion fluids known to cause a reaction when injected intravenously. The reaction is characterized in the human being and in the dog by fever, often chills, vomiting and other gastrointestinal disturbances. The fever begins 30 to 45 minutes after injection, reaches its height in 2 to 3 hours, and then begins to recede until in 4 to 6 hours it has fallen to practically normal. In all our experiments in which a leucocyte count was made, there was also found a leucopenia accompanying the reaction reaching its highest intensity 45 minutes after the injection.Seibert1 showed that the cause of this febrile reaction in some distilled waters was a gram negative microorganism which has since been called the “pyrogenic bacterium”. She further demonstrated that it was not the organism itself, but its products which caused the reaction and that the latter were filtrable through a Berkefeld filter.In our experim... |
| Databáze: | OpenAIRE |
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