Encapsulating Vesicles and Colloids from Cochleate Cylinders
| Autor: | Cara C. Evans, Joseph A. Zasadzinski |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Polystyrene spheres
Vesicle Ethylenediaminetetraacetic acid Surfaces and Interfaces Condensed Matter Physics chemistry.chemical_compound Crystallography Colloid chemistry Chemical engineering Targeted drug delivery Colloidal particle Electrochemistry General Materials Science Lipid bilayer Spectroscopy |
| Zdroj: | Langmuir. 19:3109-3113 |
| ISSN: | 1520-5827 0743-7463 |
| DOI: | 10.1021/la0265171 |
| Popis: | Encapsulating small vesicles or colloidal particles within a phospholipid bilayer affords multicompartment structures that are interesting for targeted drug delivery, imaging, or separations. Dioleoylphosphatidylserine (DOPS), an anionic lipid, forms cochleate cylinders, tightly wrapped tubes of concentric bilayers, on addition of millimolar Ca2+. Complexation of Ca2+ by the subsequent addition of ethylenediaminetetraacetic acid (EDTA) results in the unwrapping of the cochleate cylinders of DOPS sheets and reclosure to form micrometer-sized vesicles, which can entrap smaller vesicles in solution. Polystyrene spheres added to the cochleate cylinders before the EDTA unwrapping can also be enclosed. |
| Databáze: | OpenAIRE |
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