Lidocaine by Enzyme Immunoassay
| Autor: | Clifford B. Walberg |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Drug
chemistry.chemical_classification Chemical Health and Safety Chromatography Cardioactive Drugs medicine.diagnostic_test Lidocaine Chemistry Health Toxicology and Mutagenesis media_common.quotation_subject Large series Pharmacology Toxicology Analytical Chemistry Enzyme Homogeneous Immunoassay medicine Environmental Chemistry Gas liquid chromatographic media_common medicine.drug |
| Zdroj: | Journal of Analytical Toxicology. 2:121-123 |
| ISSN: | 1945-2403 0146-4760 |
| DOI: | 10.1093/jat/2.4.121 |
| Popis: | The cardioactive drug lidocaine was measured by a homogeneous enzyme immunoassay procedure (EMIT| using a procedure similar to the one described for the determination of antiepiieptic drugs in serum. The assay requires 50/al of serum per determination and less than 5 minutes to perform. The assay is specific for lidocaine and does not cross-react with lidocaine metabolites or other cardioactive drugs. Twenty replicate analyses of a serum containing lidocaine gave a CV of 3.4%. Results attained with a large series of patients administered lidocaine alone or with other cardioactive drugs were compared with results by a gas liquid chromatographic procedure. The correlation coefficient (r) was 0.976. No false postives or negatives were encountered. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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