Biomechanics, obesity, and osteoarthritis. The role of adipokines: When the levee breaks
| Autor: | Verónica López, Tamara Leonarte Pérez, Rodolfo Gómez, Oreste Gualillo, Antonio Mera, Ana Nidia Abraham Alonso, Francisca Lago, Jesús Pino, Vera Francisco, Eloy Franco, Miguel A. González-Gay |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
030203 arthritis & rheumatology
0301 basic medicine medicine.medical_specialty business.industry Adipose tissue Adipokine Inflammation Osteoarthritis Disease medicine.disease Bioinformatics Obesity Pathogenesis 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine Physical therapy Orthopedics and Sports Medicine medicine.symptom Risk factor business |
| Zdroj: | Journal of Orthopaedic Research. |
| ISSN: | 0736-0266 |
| Popis: | Osteoarthritis is a high-incidence painful and debilitating disease characterized by progressive degeneration of articular joints, which indicates a breakdown in joint homeostasis favoring catabolic processes. Biomechanical loading, associated with inflammatory and metabolic imbalances of joint, strongly contributes to the initiation and progression of the disease. Obesity is a primary risk factor for disease onset, and mechanical factors increased the risk for disease progression. Moreover, inflammatory mediators, in particular, adipose tissue-derived cytokines (better known as adipokines) play a critical role linking obesity and osteoarthritis. The present article summarizes the knowledge about the role of adipokines in cartilage and bone function, highlighting their contribution to the imbalance of joint homeostasis and, consequently, pathogenesis of osteoarthritis. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:594-604, 2018. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text