Osteoclast-activating system in cosmonauts after long-term international space station missions
| Autor: | I. B. Morukov, S. A. Ponomarev, Boris Morukov, T. A. Berendeeva, E. N. Antropova, M. P. Rykova |
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| Rok vydání: | 2016 |
| Předmět: |
musculoskeletal diseases
0301 basic medicine medicine.medical_specialty Physiology medicine.medical_treatment education 030209 endocrinology & metabolism Peripheral blood mononuclear cell Bone remodeling 03 medical and health sciences 0302 clinical medicine Osteoprotegerin Osteoclast Physiology (medical) Internal medicine medicine Receptor biology business.industry Peripheral blood 030104 developmental biology medicine.anatomical_structure Endocrinology Cytokine RANKL biology.protein business |
| Zdroj: | Human Physiology. 42:719-723 |
| ISSN: | 1608-3164 0362-1197 |
| DOI: | 10.1134/s0362119716070124 |
| Popis: | The results of studying the system of the osteoprotegerin/receptor activator of nuclear factor kappa-B ligand (OPG/RANKL) in 22 Russian cosmonauts after long-term (124–199 days) International Space Station missions are presented. It was found that early readaptation period is associated with changes in the serum concentrations of OPG and RANKL and the production rate of OPG and RANKL in phytohemagglutinin (PHA)-stimulated and non-stimulated mononuclear cells of peripheral blood in vitro. The extent of these changes varied in different subjects. Our data suggest that the OPG/RANKL cytokine system takes part in the processes of bone remodeling in cosmonauts after long-term missions. |
| Databáze: | OpenAIRE |
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