Durability of antibody responses and frequency of clinical and subclinical SARS-CoV-2 infection six months after BNT162b2 COVID-19 vaccination in healthcare workers

Autor: Alyssa R. Lindrose, Spencer L. Sterling, Julian Davies, Monique Hollis-Perry, Mimi A Wong, Yolanda Alcorta, Simon Pollett, Allison M. W. Malloy, Wei Wang, Cara H. Olsen, Eric D Laing, Emily C Samuels, Marana A Tso, Carol D. Weiss, Russell Vassell, Timothy Burgess, Richard Wang, Kathleen F Ramsey, Christopher C. Broder, David R. Tribble, Belinda M. Jackson-Thompson, Anatalio E Reyes, Luca Illinik, Si'Ana A Coggins, Emilie Goguet, Edward Mitre, Orlando Ortega, Tonia Conner, Christopher A. Duplessis, Edward Parmelee, Santina Maiolatesi, Gregory Wang
Rok vydání: 2021
Předmět:
DOI: 10.1101/2021.10.16.21265087
Popis: Antibodies against SARS-CoV-2 decay but persist six months post-vaccination, with lower levels of neutralizing titers against Delta than wild-type. Only 2 of 227 vaccinated healthcare workers experienced outpatient symptomatic breakthrough infections despite 59 of 227 exhibiting serological evidence of exposure to SARS-CoV-2 as defined by development of anti-nucleocapsid protein antibodies.
Databáze: OpenAIRE