Effects of Benidipine and Some Other Calcium Channel Blockers on the Prognosis of Patients with Vasospastic Angina

Autor:	Tomonori Segawa, Shinsuke Ojio, Toshiyuki Noda, Hisayoshi Fujiwara, Kunihiko Hiei, Katsumi Ueno, Kazuhiko Nishigaki, Hiroyoshi Ono, Hironobu Sato, Masanori Kawasaki, Kensuke Io, Shinya Minatoguchi, Genzou Takemura, Norihiko Morita, Tsutomu Tanaka, Hitoshi Matsuo, Arihiro Hattori, Toshihiko Kato, Sachiro Watanabe
Rok vydání:	2011
Předmět:	medicine.medical_specialty business.industry medicine.disease Angina chemistry.chemical_compound Nifedipine chemistry Internal medicine Coronary vasospasm Drug Discovery Benidipine medicine Cardiology Amlodipine Diltiazem Risk factor business medicine.drug Cohort study
Zdroj:	Arzneimittelforschung. 57:573-581
ISSN:	1616-7066 0004-4172
DOI:	10.1055/s-0031-1296652
Popis:	Background: It has been reported that the morbidity rate of vasospastic angina is higher in Japan compared to western countries, and its prognosis has already been reported. However, the prognosis of vasospastic angina in relation to coronary angiographic findings, prognostic risk factors and treatment has not yet been fully investigated. Methods and results: From January 2000 to October 2005, 1047 patients with va-sospastic angina diagnosed by coronary angiography at Gifu University Hospital and related hospitals were registered in a cohort study (follow-up rate: 91.4 %, median follow-up duration: 3.8 years). The presence of coronary artery stenosis, diabetes mellitus, total spasm, and age of more than 65 years had a negative prognostic impact on cardiovascular events. Patients were treated with calcium channel blockers such as diltiazem (CAS 33286-22-5, CAS 42399-41-7), am-lodipine (CAS 111470-99-6), nifedipine (CAS 21829-25-4), and benidipine (CAS 91599-74-5). Among these calcium channel blockers, when patient background was matched by the propensity score in patients treated with calcium channel blockers only, the cardiovascular event rate was significantly lower in the benid-ipine group than in the diltiazem group. Conclusion: The study demonstrated for the first time that total spasm is a risk factor, independent of other factors, for cardiovascular events in patients with va-sospastic angina. Treatment with benid-ipine showed a better prognosis than that with diltiazem.
Databáze:	OpenAIRE
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