AB0576 The frequency of autoimmune thyroid disorders in patients with psoriatic arthritis and the effect of anti tnf-alpha treatment on autoimmune thyroid disease
| Autor: | G. G. Oruk, G. Can, U. Karaoǧullarından, E. F. Tarhan |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Triiodothyronine business.industry Immunology Thyroid medicine.disease Gastroenterology General Biochemistry Genetics and Molecular Biology Rheumatology Psoriatic arthritis medicine.anatomical_structure Endocrinology Thyroid-stimulating hormone Rheumatoid arthritis Internal medicine Psoriasis medicine Immunology and Allergy Outpatient clinic business |
| Zdroj: | Annals of the Rheumatic Diseases. 72:A966.1-A966 |
| ISSN: | 1468-2060 0003-4967 |
| DOI: | 10.1136/annrheumdis-2013-eular.2898 |
| Popis: | Background Psoriatic Arthritis (PsA)is an inflammatory rheumatic disease accompanied by psoriasis. Coexistence of autoimmune thyroid disorders and rheumatic diseases such as Sjogren’s syndrome, systemic lupus erythematosus and rheumatoid arthritis has been shown in many studies. Objectives In this study, the frequency of thyroid disorders in PsA patients and the effect of anti TNF-α treatment on autoimmune thyroid disease were investigated. Methods Thyroid stimulating hormone, triiodothyronine, thyroxine, antithyroglobulin(Tg) and anti-thyroid peroxidase (TPO) of 95 patients followed at the rheumatology outpatient clinic were retrospectively evaluated. Sixty-six patients with PsA (F/M: 43/23) whose data were complete, and 35 healthy controls (F/M: 25/10) were included in the study. Thyroid ultrasonography was applied to all cases by an endocrinology specialist. Results 38 of the PsA patients received disease modifying antirheumatic drugs (DMARDs) (Group 1; mean age: 43.94±9.81), and 28 anti TNF-α treatment (Group 2; mean age:42.25±11.48). Group 3 was comprised of healthy controls (mean age: 40.52±8.34). Significant differences were observed (p Conclusions As a result, autoimmune thyroid disorders were observed more frequently in patients with PsA than in the control group. The PsA patients who are receiving DMARDs appeared to have autoimmune thyroid disorders more frequently than those receiving anti TNF-α treatment. This condition may be resulting from TNF-α on the pathogenesis of thyroid disorders. Further studies are needed to clarify this effect. Disclosure of Interest None Declared |
| Databáze: | OpenAIRE |
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