Utility of Ga 68 prostate‐specific membrane antigen positron‐emission tomography for pre‐operative staging of high‐risk prostate cancer in a prospective cohort
Autor: | Madhusudhan Prasad Koya, Devesh Datta Dixit, Andrew Keith Willams, Puja Kashyap, Remy Lim, Gregory P. Tarr |
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Rok vydání: | 2019 |
Předmět: |
medicine.medical_specialty
medicine.diagnostic_test Prostatectomy business.industry medicine.medical_treatment medicine.disease 030218 nuclear medicine & medical imaging 03 medical and health sciences Prostate cancer 0302 clinical medicine Oncology Informed consent Positron emission tomography 030220 oncology & carcinogenesis medicine Glutamate carboxypeptidase II Radiology Nuclear Medicine and imaging Radiology Stage (cooking) Pre operative staging Prospective cohort study business |
Zdroj: | Journal of Medical Imaging and Radiation Oncology. 64:78-86 |
ISSN: | 1754-9485 1754-9477 |
Popis: | INTRODUCTION To assess the yield of Ga68 PSMA PET/CT added to the conventional staging of high-risk prostate cancer in terms of altered staging and changes to management. METHODS Patients with high-risk prostate cancer without metastatic disease on conventional staging referred for Ga68 PSMA PET/CT at Mercy Radiology, Auckland, New Zealand, were prospectively recruited. Conventional staging was double read in a blinded fashion by oncology fellowship-trained radiologists, who were also experienced in PET/CT, followed by interpretation of the PSMA PET/CT by the same radiologists. Confirmation of changes in management decision was obtained from the treating surgeon and multidisciplinary team meeting records. Ethical approval was obtained from the Health and Disability Ethics Committee. All patients gave written informed consent. RESULTS A total of 49 patients were scanned. Three who were otherwise eligible for radical prostatectomy elected alternative treatments, leaving 46 patients included for analysis in the study. The addition of PSMA PET/CT was associated with highly statistically significant changes in both staging and management. The stage was changed in 32.6% (95% CI 20.8-47.1%, P |
Databáze: | OpenAIRE |
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