Utility of Ga 68 prostate‐specific membrane antigen positron‐emission tomography for pre‐operative staging of high‐risk prostate cancer in a prospective cohort

Autor: Madhusudhan Prasad Koya, Devesh Datta Dixit, Andrew Keith Willams, Puja Kashyap, Remy Lim, Gregory P. Tarr
Rok vydání: 2019
Předmět:
Zdroj: Journal of Medical Imaging and Radiation Oncology. 64:78-86
ISSN: 1754-9485
1754-9477
Popis: INTRODUCTION To assess the yield of Ga68 PSMA PET/CT added to the conventional staging of high-risk prostate cancer in terms of altered staging and changes to management. METHODS Patients with high-risk prostate cancer without metastatic disease on conventional staging referred for Ga68 PSMA PET/CT at Mercy Radiology, Auckland, New Zealand, were prospectively recruited. Conventional staging was double read in a blinded fashion by oncology fellowship-trained radiologists, who were also experienced in PET/CT, followed by interpretation of the PSMA PET/CT by the same radiologists. Confirmation of changes in management decision was obtained from the treating surgeon and multidisciplinary team meeting records. Ethical approval was obtained from the Health and Disability Ethics Committee. All patients gave written informed consent. RESULTS A total of 49 patients were scanned. Three who were otherwise eligible for radical prostatectomy elected alternative treatments, leaving 46 patients included for analysis in the study. The addition of PSMA PET/CT was associated with highly statistically significant changes in both staging and management. The stage was changed in 32.6% (95% CI 20.8-47.1%, P
Databáze: OpenAIRE
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