Risk of hospitalization for upper gastrointestinal tract complications associated with non-selective non-steroidal anti-inflammatory drugs in Malaysia: a retrospective case control study

Autor: Jayaram Menon, Kanagasabai Ganesalingam, Elke Hunsche, Eng Jin Ooi, Yen Yew Ngau, Swee Pei Thong, Singh Matvinder, Jaxinthe Siew Kuen Ong, Panagiotis Mavros, John L.S. Cheng, Shashi Kumar Menon, Siang Tong Kew, Shanmuganathan Ganesanathan
Rok vydání: 2004
Předmět:
Zdroj: APLAR Journal of Rheumatology. 7:196-203
ISSN: 1479-8077
DOI: 10.1111/j.1479-8077.2004.00094.x
Popis: Aims: To assess the association between non-steroidal anti-inflammatory drug (NSAID) use and upper gastrointestinal (GI) tract-related hospitalizations and to evaluate inpatient healthcare resource utilization associated with these complications in Malaysia. Methods: A retrospective case control study was performed using medical records of patients admitted to two Malaysian hospitals during 1999 and 2000. Cases were identified based on mode of presentation at hospital admission. One control was identified for each case, matched by age, sex and admission date. NSAID exposure was determined by drug use during one year prior to admission. Conditional logistic regression analysis was used to determine the association between NSAID use and upper GI complications, adjusting for predictors. Results: The 273 cases were significantly more likely to have used NSAIDs in the year prior to hospitalization than controls (27.8%vs. 6.2% of patients; P
Databáze: OpenAIRE