Facile coupling of 2-(1-ethylthioethenyl)pyrroles with amines: A route to 2-(1-aminoethenyl)pyrroles and 1-amino-3-iminopyrrolizines

Autor:	Olga V. Petrova, Al'bina I. Mikhaleva, Leonid B. Krivdin, Vladislav N. Drichkov, Ol'ga A. Tarasova, D. S. D. Toryashinova, Lyubov N. Sobenina, Boris A. Trofimov, Yuriy Yu. Rusakov, Igor A. Ushakov
Rok vydání:	2007
Předmět:	Coupling (electronics) chemistry.chemical_compound Primary (chemistry) chemistry Ethanethiol Organic Chemistry Moiety Medicinal chemistry
Zdroj:	Journal of Heterocyclic Chemistry. 44:505-513
ISSN:	1943-5193 0022-152X
DOI:	10.1002/jhet.5570440301
Popis:	2-(2-Cyano-1-ethylthioethenyl)pyrroles are readily coupled (50–55°) with primary and secondary amines at the position 1 of the ethenyl moiety to eliminate ethanethiol and afford 2-(1-amino-2-cyanoethenyl)pyrroles and/or their cyclic isomers - functionalized 1-amino-3-iminopyrrolizines in good to high yields.
Databáze:	OpenAIRE
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