An epidemiologic research design using the Annual of the Pathological Autopsy Cases in Japan

Autor:	Takanori Ogawa, Akira Babazono, Toshihide Tsuda, Eiji Yamamoto, Hideyasu Aoyama, Yoshio Mino, Jun Shigemi
Rok vydání:	1994
Předmět:	Selection bias medicine.medical_specialty Pathology business.industry media_common.quotation_subject Case-control study Autopsy General Medicine Odds ratio Epidemiology Medicine Epidemiologic research Information bias business Pathological media_common Demography
Zdroj:	Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene). 49:753-761
ISSN:	1882-6482 0021-5082
DOI:	10.1265/jjh.49.753
Popis:	Epidemiologic research designs using the Annual of the Pathological Autopsy Cases in Japan (APAC hereinafter) are discussed in this paper. The APAC data base has been recommended for use in epidemiologic research. However, it has not often been utilized for such research, even though it covers all pathological autopsy cases in Japan, perhaps because of different sampling proportions of each disease and because of the dead control series in APAC. First, we present epidemiologic measures in using the APAC. We show that the data base can be treated as a case-control design and that the magnitude of the exposure effect should be estimated by an odds ratio. Next, selection bias and information bias in using the APAC are discussed. The independence of the control series from the exposure is important in the determination of the control disease. Because this design is based on intenal comparison, non-differential misclassification should be stressed more than differential misclassification.
Databáze:	OpenAIRE
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