3D-printed PEEK reactors and development of a complete continuous flow system for chemical synthesis
| Autor: | Thomas Ziegler, Jochen M. Neumaier, Thomas Klein, Florian Menzel |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Fluid Flow and Transfer Processes
Syringe driver chemistry.chemical_classification Materials science Back pressure Process Chemistry and Technology education Microfluidics Separator (oil production) Polymer Flow chemistry Catalysis Polyether ether ketone chemistry.chemical_compound chemistry Chemical engineering Chemistry (miscellaneous) Peek Chemical Engineering (miscellaneous) |
| Zdroj: | Reaction Chemistry & Engineering. 5:1300-1310 |
| ISSN: | 2058-9883 |
| DOI: | 10.1039/d0re00206b |
| Popis: | The possibility of 3D printing high temperature and chemically resistant polymers creates opportunities for applications in flow chemistry. Herein we describe the development of milli- and microfluidic reactors made of polyether ether ketone (PEEK) with a high temperature 3D printer and examine their mixing performance and suitability for flow reactions at elevated temperatures. Additionally, we present a 3D-printed separator, back pressure regulator and continuous syringe pump, which provide a complete flow system for a fraction of the cost of commercially available flow equipment. Different 3D printed mixing geometries were tested and the influence of mixing on fluorination of a ribose derivative was evaluated. To demonstrate the usability of our self-made flow equipment we performed a multistep reaction of a ribose derivative in excellent yield which could be used as a precursor for the synthesis of nucleoside anti-cancer drugs. |
| Databáze: | OpenAIRE |
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