Protective Effects and Mechanisms of Pourthiaea villosa (Thunb.) Decne. Extract on Hydrogen Peroxide-Induced Skin Aging in Human Dermal Fibroblasts
| Autor: | Bong-Yeon Cho, Young-Cheul Kim, Seung-Hyun Choi, Il-Jun Kang, Xionggao Han, Jong-Seok Lee, Wan-Sup Sim, Boo-Yong Lee, Sarah Lee, Ok-Hwan Lee, Sun-Il Choi |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification Reactive oxygen species 030109 nutrition & dietetics Nutrition and Dietetics Antioxidant ABTS integumentary system Chemistry DPPH medicine.medical_treatment Flavonoid Medicine (miscellaneous) Pharmacology Skin Aging Dermal fibroblast 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine 030220 oncology & carcinogenesis medicine Hydrogen peroxide |
| Zdroj: | Journal of Medicinal Food. 22:841-850 |
| ISSN: | 1557-7600 1096-620X |
| DOI: | 10.1089/jmf.2018.4379 |
| Popis: | Skin aging is associated with increased reactive oxygen species (ROS) produced by human cells. These radicals are the main causes of skin aging, and skin cells have developed antioxidant enzymes for protection against ROS-induced damage. Antioxidants play critical roles to prevent ROS-induced aging symptoms. In this study, the antioxidant properties of Pourthiaea villosa (Thunb.) Decne. extract (PVDE) were studied. Human dermal fibroblast (HDF) cells were treated with PVDE to evaluate its antioxidant and antiaging activities and to investigate the underlying mechanisms. The identified compounds were polyols, and phenolic and flavonoid compounds from PVDE by UHPLC-LTQ-IT-MS/MS. PVDE exhibited significant antioxidant effects, as evaluated with reducing power, and ABTS and DPPH radical scavenging activity. Furthermore, PVDE treatment significantly increased antioxidant enzyme expressions and effectively blocked H2O2-induced matrix metalloproteinase activity through MAPK signaling pathways in HDFs. Therefore, these results showed that PVDE affords an advantage of being a functional natural material with antioxidant and antiaging effects for the skin. |
| Databáze: | OpenAIRE |
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