Hemodynamic and regional blood flow studies in the normotensive and spontaneously hypertensive rat: Application of the radioactive microsphere technique
| Autor: | Ravinder K. Saini, Pitambar Somani |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Pharmacology
medicine.medical_specialty Cardiac output Radioactive microsphere technique business.industry Hemodynamics Blood flow Hypoxia (medical) medicine.anatomical_structure Endocrinology Spontaneously hypertensive rat Blood pressure Ventricle Anesthesia Internal medicine medicine medicine.symptom business |
| Zdroj: | Journal of Pharmacological Methods. 2:357-369 |
| ISSN: | 0160-5402 |
| DOI: | 10.1016/0160-5402(79)90028-7 |
| Popis: | Radioactive microspheres (9 ± 1 μ.) labeled with one of the three isotopes (85Sr, 141Ce, or 51Cr) were injected directly into the left ventricle of anesthetized closed-chest spontaneously hypertensive rats (SHR) or normal (WKY) rats. The microspheres were injected into each animal at three different time intervals: during control conditions, during hypoxia, and after recovery from hypoxia. A reference blood sample technique was used for simultaneous measurement of the cardiac output (CO). Heart rate (HR) and aortic blood pressure (AOP) were also recorded throughout the experiment. The SHR had a significantly higher AOP and resistance, but there was no difference in HR or CO as compared to the WKY rats. The blood flow distribution to various organs in the two strains of rats was not significantly different. Both groups of rats responded with a marked decrease in flows to various organs during hypoxia; however, only blood flows to the heart and eyes were different in the two strains of rats during hypoxia. The mechanism of slow posthypoxic recovery in SHR as compared to WKY is discussed. The technique of microsphere distribution in small animals, especially SHR, can be applied to investigate the effect of various drugs on hemodynamics and blood flow distribution to different organs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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