Differential scanning calorimetry study of early and advanced stages in Parkinson’s disease using human blood serum
| Autor: | Ewa Sadowska-Krępa, Joanna Cholewa, Izabela Schisler, Anna Michnik, Zofia Drzazga, Agnieszka Kiełboń |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Parkinson's disease Human blood business.industry Advanced stage Calorimetry Condensed Matter Physics medicine.disease 01 natural sciences Gastroenterology 010406 physical chemistry 0104 chemical sciences 03 medical and health sciences 0302 clinical medicine Differential scanning calorimetry Blood serum Disease severity Internal medicine Advanced disease medicine Physical and Theoretical Chemistry business Instrumentation 030217 neurology & neurosurgery |
| Zdroj: | Thermochimica Acta. 662:64-68 |
| ISSN: | 0040-6031 |
| DOI: | 10.1016/j.tca.2018.02.014 |
| Popis: | The study evaluates the use of differential scanning calorimetry (DSC) in differentiating the severity of Parkinson’s disease (PD). The heat capacity profiles and thermodynamic parameters of serum denaturation transition in advanced PD deviate significantly from the age-matched healthy controls. Unfortunately, blood serum calorimetry does not indicate the early stages of the disease. The amplitude of the main transition and the enthalpy of serum denaturation are significantly reduced with advanced disease. Statistically significant, inverse correlations have been found between these parameters and age as well as disease severity. Significantly higher mean temperature of the second transition at about 70 C, has been observed for PD patients in comparison with healthy participants but only small its deviations have appeared across disease groups. Results of the study indicate that DSC can be used as complementary bioanalytical tool for the monitoring of disease-related changes in serum and PD progression. |
| Databáze: | OpenAIRE |
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