Budesonide enema in pouchitis-a double-blind, double-dummy, controlled trial

Autor:	I. Doldán, A. Gil, A. Graziano, H. Peredo, Julio C. Bai, Luis A. Boerr, O Gonzalez, Emilia Sugai, Ana Cabanne, S. Negreira, G Camartino, M Lumi, A. Sambuelli, S. Huernos, Zulema Kogan
Rok vydání:	2002
Předmět:	Budesonide medicine.medical_specialty Hepatology business.industry medicine.medical_treatment Gastroenterology Pouchitis Enema medicine.disease Placebo Ulcerative colitis Surgery law.invention Metronidazole Tolerability Randomized controlled trial law Internal medicine medicine Pharmacology (medical) business medicine.drug
Zdroj:	Alimentary Pharmacology & Therapeutics. 16:27-34
ISSN:	0269-2813
Popis:	Background: Pouchitis has been suggested to be a recurrence of ulcerative colitis in a colon-like mucosa. Topical steroids are a valid therapeutic alternative for distal forms of ulcerative colitis. Aim: To investigate the efficacy and tolerability of budesonide enema in the treatment of pouchitis compared with oral metronidazole. Materials and methods: Twenty-six patients with an active episode of pouchitis (defined as a pouchitis disease activity index score ≥ 7) and no treatment during the previous month were randomized to receive either budesonide enema (2 mg/100 mL at bedtime) plus placebo tablets or oral metronidazole (0.5 g b.d.) plus placebo enema in a prospective, double-blind, double-dummy, 6-week, controlled trial. Results: Based on the intention-to-treat principle, we detected a significant improvement in disease activity at the end of the first week with both drugs (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f12c5c9368f9286d2619ceb099e5a5cd https://doi.org/10.1046/j.1365-2036.2002.01139.x Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.