Metabolic regulation of tissue-resident memory CD8+ T cells
| Autor: | Henrique Borges da Silva, Jie Sun, Trupti Vardam-Kaur |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Pharmacology T cell P2RX7 Mitochondrion Biology 030226 pharmacology & pharmacy Cell biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Drug Discovery medicine Cytotoxic T cell CD8 Homeostasis Intracellular Function (biology) |
| Zdroj: | Current Opinion in Pharmacology. 57:117-124 |
| ISSN: | 1471-4892 |
| Popis: | Intracellular metabolic adaptations help define the function and homeostasis of memory CD8+ T cells. These cells, which promote protection against infections or cancer, undergo consecutive metabolic shifts, ultimately relying on mitochondrial-related pathways. Past CD8+ T cell metabolism studies focused on circulating memory cells, which are exclusive to secondary lymphoid organs or recirculate between lymphoid and non-lymphoid organs. Yet, now there is unequivocal evidence that memory CD8+ T cells reside in many non-lymphoid organs and mediate protective immunity in barrier tissues. The metabolic adaptations occurring in forming and established tissue-resident memory CD8+ T cells are currently subject of intense research. In this review, we discuss the latest breakthroughs on the transcriptional and protein control of tissue-resident memory CD8+ T cell metabolism. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect