The preparation of (perfluoroalkyl)imidazoles as nonpeptide angiotensin II receptor antagonists

Autor:	Andrew T. Chiu, Pieter B.M.W.M. Timmermans, Alexander L. Johnson, Pancras C. Wong, David J. Carini, Ruth R. Wexler
Rok vydání:	1993
Předmět:	medicine.medical_specialty Angiotensin receptor Chemistry Organic Chemistry Clinical Biochemistry Pharmaceutical Science Pharmacology Selective antagonist Biochemistry Angiotensin II Blood pressure Endocrinology Internal medicine Drug Discovery dup medicine Molecular Medicine Molecular Biology
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 3:895-898
ISSN:	0960-894X
DOI:	10.1016/s0960-894x(00)80688-5
Popis:	A series of (perfluoroalkyl)imidazoles have been prepared and are potent angiotensin II antagonists. One of these compounds, DuP 532, 4-pentafluoroethyl-2-propyl-1-[[2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]imidazole-5-carboxylic acid, is a selective antagonist of angiotensin II which causes a marked and long-lasting drop in blood pressure when administered orally to a renal hypertensive rat.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f11bef201ae39dd552c2a8617911e51f https://doi.org/10.1016/s0960-894x(00)80688-5 Zobrazit plný text záznamu