Effect of heparin in anticoagulant doses on the electrocardiogram and cardiac enzymes in patients with acute myocardial infarction
| Autor: | David G. Marsh, Michael J. Saliba, William J. Kuzman, James E. Lasry |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test medicine.drug_class business.industry Anticoagulant Ischemic injury Heparin medicine.disease Intestinal mucosa Internal medicine medicine Cardiology Cardiac enzymes In patient Myocardial infarction Cardiology and Cardiovascular Medicine business Electrocardiography medicine.drug |
| Zdroj: | The American Journal of Cardiology. 37:605-607 |
| ISSN: | 0002-9149 |
| DOI: | 10.1016/0002-9149(76)90402-1 |
| Popis: | The effect of heparin in clinical anticoagulant doses on S-T segment and cardiac enzymes was studied in 18 patients with acute myocardial infarction by electrocardiogram and enzyme evaluation 1 hour and 24 hours after initial heparin infusion. Intestinal mucosa heparin was given by infusion, 10,000 units after the admission electrocardiogram, and 5,000 units every 6 hours. Data in the nine control and nine treated patients were statistically similar on admission. The electrocardiograph findings were improved, but not significantly, 1 hour after administration of heparin. At 24 hours of heparin therapy, the S-T deviations were reduced 64% (from 139 +/- 2.1 [standard error of the mean] to 50.5 +/- 1.2 mm); in control patients S-T deviations were reduced 21% (from 109 +/- 1.8 to 86 +/- 0.9 mm (t=2.9, P less than 0.019). At 24% hours electrocardiographic leads with 2 mm or more deviation were reduced 86% in heparin-treated patients and 28% in control subjects. Cardiac enzymes were comparably elevated at 24 and 48 hours in both groups, with no clear trend. It is concluded that heparin in anticoagulant doses reduces the 12 lead electrocardiographic pattern of injury without discernibly modifying cardiac enzymes. The question of heparin efficacy in acute myocardial ischemic injury, reopened by findings with large dose heparin in therapy in dogs and anticoagulant dose in this study, awaits further expanded investigation. |
| Databáze: | OpenAIRE |
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